Which of the following digestive enzymes would be greatly affected if the liver fails to produce bile?

Analyze the question: Bile is produced by the liver and stored in the gall bladder. The question asks which digestive enzyme would be greatly affected if bile is not produced.

Explain the concept: Bile contains no enzymes. Its main job is to emulsify fats, breaking large fat globules into tiny droplets. This greatly increases the surface area for the enzyme lipase to act on. Bile also provides an alkaline medium (neutralizing acid chyme from the stomach), which helps pancreatic and intestinal enzymes work well.

Step-by-step solution:

1. Amylase digests starch to maltose. It works in the mouth and the small intestine and does not depend on bile for its action. Not greatly affected.
2. Cellulase digests cellulose. Humans do not produce it, so it is irrelevant here.
3. Lipase digests fats (lipids) into fatty acids and glycerol. Without bile, fats are not emulsified, so lipase has a much smaller surface area to work on and fat digestion is poor. This is greatly affected.
4. Protease (written "rotease" in the question, clearly a typo) digests proteins into amino acids. Protein digestion starts in the stomach with pepsin and does not depend on bile emulsification. Not greatly affected.

Answer: The enzyme most affected is lipase, which is option C.

Tip: Remember "Bile Breaks fat into Bubbles (emulsifies)", so think Bile → fats → Lipase. Bile itself is not an enzyme, but it helps the fat-digesting enzyme do its job.